Catalyst‐Free Indirect C–F Activation of 3‐Perfluoroalkyl Indoles

Thomas Roider, Olaf A. Kleykamp,Sergei I. Ivlev,Reinhard W. Hoffmann,Ulrich Tallarek

European Journal of Organic Chemistry（2022）

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摘要

We present a catalyst-free method for indirect C-F activation of a perfluorinated side chain in C-(3) position of 1H-indoles with moderate to good yields, which allows the introduction of a nucleophile at the alpha-CF2-group of the perfluorinated chain. By adapting this approach, it is also possible to modify 3-perfluorobutyl-2-phenyl-1H-indole to generate privileged structures for medicinal chemistry.

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关键词

Catalyst-free, Flow chemistry, Indirect C-F Activation, Photochemistry

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