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SIRT2 promotes cell proliferation and migration through mediating ERK1/2 activation and lactosylceramide accumulation in prostate cancer.

Rui Lin,Yiping Yang, Eran Wu, Menghan Zhou,Shan Wang,Qingyun Zhang

The Prostate（2023）

Cited 3|Views7
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Abstract
Our data suggested that SIRT2 is overexpressed in CRPC and NEPC and could promote cell growth and migration through activating ERK1/2 pathway and inducing lactosylceramide production, indicating that SIRT2 has the potential to be a new target for the treatment of PCa.
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Key words
ERK1/2,SIRT2,cell proliferation,lactosylceramide,migration,prostate cancer
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