Progress in mesenchymal stem cell mitochondria transfer for the repair of tissue injury and treatment of disease

Biomedicine & Pharmacotherapy(2022)

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摘要
Mesenchymal stem cells (MSCs) have therapeutic value in many diseases. Mitochondria transfer can promote wound healing and can potentially be applied to the repair of damaged tissue, but the specific mechanisms and regulatory factors involved remain unclear. In this review, we discuss the mechanistic basis of mitochondria transfer and factors that restore mitochondrial function in injured somatic cells.
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关键词
MSCs,TNTs,MVs,EVs,GJs,GJCs,GJIC,Cx,Miro1,AAI,LPS,BM-MSCs,NF-κB,HUVECs,hBMSCs,TNF-α,ROS,hMSCs,H/R,NMCMs,PMVECs,ARDS,AM
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