Finding a chaperone for TDP-43
NATURE CELL BIOLOGY(2022)
摘要
ggregation of the RNA-binding protein TDP-43 is commonly observed in neurodegenerative disorders. A new study reveals that this process may be blocked by HSPB1, a small heat shock protein that can also regulate TDP-43 phase separation. This may be relevant to neurodegeneration, as loss of HSPB1 correlates with TDP-43 pathology.
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关键词
Chaperones,Mechanisms of disease,Protein aggregation,RNA-binding proteins,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
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