Recombinant human erythropoietin induces neuroprotection, activates MAPK/CREB pathway, and rescues fear memory after traumatic brain injury with delayed hypoxemia in mice

Marta Celorrio,James Rhodes,Kirill Shumilov,Jennie Moritz,Sophia Xiao,Ilakkia Anabayan,Andrew Sauerbeck,Terrance Kummer,Stuart Friess

Brain Research（2022）

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摘要

•rhEPO treatment induces neuroprotection 1 month and 6 months after TBI and delayed hypoxemia.•Ongoing rhEPO activates amygdalar MAPK/CREB signaling pathway.•Ongoing rhEPO recues cued fear memory.•Ongoing rhEPO increases post-TBI adult hippocampal neurogenesis in dentate gyrus.•rhEPO treatment increases synaptic density in the hippocampus and amygdala at 6 months post-injury.

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关键词

TBI,EPO,rEPO,CCI,NOR,MAPK/CREB,CeA,SEQUIN

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