E6E7 regulates the HK2 expression in cervical cancer via GSK3β/FTO signal

Chunyan Liu,Yangyang Li,Changyan Dong,Luyun Qu,Ying Zuo

Archives of Biochemistry and Biophysics（2022）

引用 3|浏览4

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摘要

This study found that E6E7 oncogene activates the transcription of GSK3β; GSK3β can promote the ubiquitination-proteasomal degradation of FTO and reduce the level of FTO protein; FTO inhibits the maturation and translation of HK2 mRNA by retaining HK2 pre-mRNA in the nucleus.

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关键词

E6E7 oncogene,Kinase,Ubiquitination-proteasomal degradation,Nuclear retention

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