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Risk Factors for Heart Failure Among Pan-European Childhood Cancer Survivors: A PanCareSurFup and ProCardio Cohort and Nested Case-Control Study.

Esmée C de Baat,Elizabeth A M Feijen,Raoul C Reulen,Rodrigue S Allodji,Francesca Bagnasco,Edit Bardi,Fabiën N Belle,Julianne Byrne,Elvira C van Dalen,Ghazi Debiche,Ibrahima Diallo,Desiree Grabow,Lars Hjorth,Momcilo Jankovic,Claudia E Kuehni,Gill Levitt,Damien Llanas,Jacqueline Loonen,Lorna Z Zaletel,Milena M Maule,Lucia Miligi,Helena J H van der Pal,Cécile M Ronckers, Carlotta Sacerdote,Roderick Skinner,Zsuzsanna Jakab,Cristina Veres,Nadia Haddy,David L Winter,Florent de Vathaire,Michael M Hawkins, Leontien C M Kremer

Journal of clinical oncology : official journal of the American Society of Clinical Oncology（2023）

Cited 6|Views50
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Abstract
Survivors who received a mean heart RT dose of ≥ 5 Gy have an increased risk of HF. The risk associated with RT increases with larger volumes exposed. Survivors treated with < 100 mg/m total cumulative anthracycline dose have no significantly increased risk of HF. These new findings might have consequences for new treatment protocols for children with cancer and for cardiomyopathy surveillance guidelines.
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Key words
heart failure,procardio cohort,risk factors,cancer,pancaresurfup,pan-european,case-control
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