Network analysis between neuron dysfunction and neuroimmune response based on neural single-cell transcriptome of COVID-19 patients

Xiaoyu Lin,Huan Nie,Ran Tang,Pingping Wang,Xiyun Jin,Qinghua Jiang,Fang Han,Na Chen,Yu Li

Computers in Biology and Medicine（2022）

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摘要

Despite global vaccination efforts, COVID-19 breakthrough infections caused by variant virus continue to occur frequently, long-term sequelae of COVID-19 infection like neuronal dysfunction emerge as a noteworthy issue. Neuroimmune disorder induced by Inflammatory factor storm was considered as a possible reason, however, little was known about the functional factors affecting neuroimmune response to this virus.

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COVID-19,scRNA-seq,Neuroimmune characteristics,Neural sequelae,Risk model

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