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A high interferon gamma signature of CD8 + T cells predicts response to neoadjuvant immunotherapy plus chemotherapy in gastric cancer.

Sen Li,Ke Li,Fei Tian,Hongle Li,Qingxin Xia,Tiepeng Li,Bing Dong,Danyang Li,Juan Yu,Junli Zhang,Li Wang,Chengjuan Zhang,Shuning Xu,Yuzhou Zhao,Ying Liu

Frontiers in immunology（2022）

Cited 4|Views10
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Abstract
Our data reveal interactions between the TME and neoadjuvant immunotherapy plus chemotherapy in GC. Importantly, it also highlights the signature of CD8 T cells in predicting response to the combination therapy in GC.
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Key words
gastric cancer,immune checkpoint blockade,interferon gamma,neoadjuvant immunotherapy,single-cell RNA sequencing,tumor microenvironment
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