Insight into the release mechanisms of diflunisal and salicylic acid from poly(vinyl alcohol). The role of hydrogen bonding interactions.

Marta Miotke-Wasilczyk,Jerzy Kwela,Aneta Lewkowicz,Marek Józefowicz

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy（2023）

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Abstract

•Solvent-dependent photophysical properties of SAL and DIF are investigated.•The solvation of DIF and SAL is determined by dipolar and hydrogen bonding interactions.•Molecular structure of the drug entrapped in matrix affects the polymer tacticity.•DIF and SAL release kinetics from PVA are influenced by specific drug-polymer interactions.

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Key words

Drug carrier,Drug release kinetics,Drug-matrix interactions,Hydrogen bonding,Diflunisal,Solvatochromism

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