Burning the Candle at Both Ends-Sleep Quality Before and After Chemotherapy in Lung Cancer Patients - A Systematic Review and Meta-Analysis

Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. Although sleep affects both biological and psychological functioning and quality of life, it is a largely under-reported problem in LC. Furthermore, systemic chemotherapy is a standard of care for most people with advanced stage disease, yet research on the impact of chemotherapy for LC on sleep quality is inconsistent. Understanding sleep quality before and after chemotherapy for LC is important for future intervention research and resource allocations to improve patient quality of life. We conducted a systematic review with two aims: 1) To determine the prevalence and severity of sleep disturbance in LC patients; and, 2) Does sleep quality differ before and after chemotherapy treatment in LC patients.