MA02.03 the Evolution of Lung Neuroendocrine Tumors

In the context of the lungNENomics project, we have generated comprehensive molecular profiles of the rare and understudied lung neuroendocrine tumors (LNETs). We revealed three molecular groups of LNETs that challenge the current WHO classification: low-aggressive groups A1 and A2, and the more aggressive group B. Additionally, we revealed the existence of a subgroup of very aggressive LNETs, that we named supra-carcinoids, with the histopathological features of LNETs but the molecular and clinical characteristics of the higher-grade large-cell neuroendocrine carcinoma. Nevertheless, how tumors from each molecular group originate, and how some tumors evolve toward more aggressive phenotypes remains a mystery.