Neuronally expressed PDL1, not PD1, suppresses acute nociception

Kimberly A. Meerschaert,Brian S. Edwards,Ariel Y. Epouhe, Bahiyyah Jefferson,Robert Friedman,Olivia L. Babyok,Jamie K. Moy, Faith Kehinde,Chang Liu,Creg J. Workman,Dario A.A. Vignali,Kathryn M. Albers,H. Richard Koerber,Michael S. Gold, Brian M. Davis,Nicole N. Scheff,Jami L. Saloman

Brain, Behavior, and Immunity（2022）

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摘要

•PDL1, but not PD1, is widely expressed in murine and human sensory neurons.•PD1 inhibits capsaicin-evoked behaviors and Ca2+ via reduction of membrane TRPV1.•Anti-nociceptive effects of exogenous PD1 require neuronally expressed PDL1.

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关键词

Analgesia,DRG,Neuroimmune,Nociceptor sensitization,Reverse signaling,Sex difference

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