P2.12-05 Cancer and Atopy: Parallel Drivers? IL-4 Blockade Synergizes with PD-L1 Blockade to Reverse Type-2Mediated Immunosuppression

Type-2 cytokines, such as IL-4, alter macrophage immunogenicity in vitro leading to the M1/M2 paradigm, however, the role of IL-4 in-vivo in cancer remains unclear. Using high dimensional immune profiling of human NSCLC lesions we previously described several functionally distinct populations of macrophages, and a tumor-enriched dendritic cell program of concomitant immunosuppression and activation which we termed the mregDC, and we identified analogous cells in a murine model of lung cancer (Maier et al, Nature 2020, Casanova-Acebes et al, Nature, 2021, Leader et al, Cancer Cell 2021).