EP16.02-008 Cerebrospinal Fluid as a Liquid Biopsy for Molecular Characterization of Brain Metastases in Patients With Non-small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) with brain metastases (BM) is a challenging clinical issue with poor prognosis. Studies conducted with paired molecular analyses of BM and primary tumors have revealed clonal evolution and substantial differences in gene expression. No data exist regarding extensive molecular analysis of cerebrospinal fluid (CSF) and its correlation to different compartments.