Integrated analysis of effect of daisaikoto, a traditional Japanese medicine, on the metabolome and gut microbiome in a mouse model of nonalcoholic fatty liver disease

Shiori Ishizawa,Akinori Nishi,Noriko Kaifuchi,Chika Shimobori,Miwa Nahata,Chihiro Yamada,Seiichi Iizuka,Katsuya Ohbuchi,Mitsue Nishiyama,Naoki Fujitsuka,Toru Kono,Masahiro Yamamoto

Gene（2022）

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摘要

•Daisaikoto ameliorated the nonalcoholic fatty liver disease activity score of STAM mice.•Daisaikoto decreased the levels of several liver lipid mediators such as arachidonic acid and its derivatives.•Daisaikoto administration improved this imbalance in microbiome composition.•Daisaikoto increased ursodeoxycholic acid content and altered several amino acids in stool.

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关键词

Daisaikoto,Traditional Japanese medicine,Nonalcoholic fatty liver disease,Gut microbiome,Metabolome

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