Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease. Daniel H Leung , Sridevi Devaraj , Nathan P Goodrich , Xinpu Chen , Deepthi Rajapakshe , Wen Ye , Victor Andreev , Charles G Minard , Danielle Guffey , Jean P Molleston , Lee M Bass , Saul J Karpen , Binita M Kamath , Kasper S Wang , Shikha S Sundaram , Philip Rosenthal , Patrick McKiernan , Kathleen M Loomes , M Kyle Jensen , Simon P Horslen , Jorge A Bezerra , John C Magee , Robert M Merion , Ronald J Sokol , Benjamin L Shneider , Estella Alonso , Lee Bass , Susan Kelly , Mary Riordan , Hector Melin-Aldana , Jorge Bezerra , Kevin Bove , James Heubi , Alexander Miethke , Greg Tiao , Julie Denlinger , Erin Chapman , Ronald Sokol , Amy Feldman , Cara Mack , Michael Narkewicz , Frederick Suchy , Shikha S Sundaram , Johan Van Hove , Benigno Garcia , Mikaela Kauma , Kendra Kocher , Matthew Steinbeiss , Mark Lovell , Kathleen M Loomes , David Piccoli , Elizabeth Rand , Pierre Russo , Nancy Spinner , Jessi Erlichman , Samantha Stalford , Dina Pakstis , Sakya King , Robert Squires , Rakesh Sindhi , Veena Venkat , Kathy Bukauskas , Patrick McKiernan , Lori Haberstroh , James Squires , Philip Rosenthal , Laura Bull , Joanna Curry , Camille Langlois , Grace Kim , Jeffery Teckman , Vikki Kociela , Rosemary Nagy , Shraddha Patel , Jacqueline Cerkoski , Jean P Molleston , Molly Bozic , Girish Subbarao , Ann Klipsch , Cindy Sawyers , Oscar Cummings , Simon P Horslen , Karen Murray , Evelyn Hsu , Kara Cooper , Melissa Young , Laura Finn , Binita M Kamath , Vicky Ng , Claudia Quammie , Juan Putra , Deepika Sharma , Aishwarya Parmar , Stephen Guthery , Kyle Jensen , Ann Rutherford , Amy Lowichik , Linda Book , Rebecka Meyers , Tyler Hall , Kasper S Wang , Sonia Michail , Danny Thomas , Catherine Goodhue , Rohit Kohli , Larry Wang , Nisreen Soufi , Daniel Thomas , Saul Karpen , Nitika Gupta , Rene Romero , Miriam B Vos , Rita Tory , John-Paul Berauer , Carlos Abramowsky , Jeanette McFall , Benjamin L Shneider , Sanjiv Harpavat , Paula Hertel , Daniel Leung , Mary Tessier , Deborah Schady , Laurel Cavallo , Diego Olvera , Christina Banks , Cynthia Tsai , Richard Thompson , Edward Doo , Jay Hoofnagle , Averell Sherker , Rebecca Torrance , Sherry Hall , John Magee , Robert Merion , Cathie Spino , Wen Ye Hepatology（2023）
摘要
Endoglin, IL-8, and MMP-7 significantly correlate with increased LSM in children with BA, whereas CTGF inversely correlates with LSM in participants with A1AT; these biomarkers appear to enhance prediction of LSM beyond clinical tests. Future disease-specific investigations of change in these biomarkers over time and as predictors of clinical outcomes will be important.
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pediatric cholestatic liver disease, liver stiffness, serum biomarkers
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