Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic lipolysis in rat

Zejian Liu,Lingyu Zhang,Chen Qian,Ying Zhou,Qiuyu Yu,Jiaqi Yuan, Yunfan Lv, Leheng Zhang,Xiaoai Chang,Yangyang Li,Yu Liu

Metabolism（2022）

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摘要

•Recurrent hypoglycemia (RH) increases adrenergic sensitivity in liver and visceral fat.•RH enhances hepatic gluconeogenesis by facilitating lactate uptake.•RH increases lipogenesis without affecting systemic lipolysis.•RH accelerates glucose disposal into visceral adipose tissue via upregulated GLUT4.

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关键词

3dRH,ADRA1B,ADRB,AGL,AQP,ARRB,ATGL,BG,EGP,ETT,eWAT,FABPpm,FATP,FBP1,G6PC,GCGR,GK,GLUT,GOT2,GPCRs,GRKs,GYS,HSL,IIT,ITT,i.p.,iWAT,LDH,LTT,MCT,PC,PCK,PTT,PYGL,PYGM,RE,RH,STZ,TA

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