The Yucatan minipig model: A new preclinical model of malnutrition induced by a low-calorie/low-protein diet

Laurence Lacaze,Sarah Rochdi, Annaëlle Couvert, Steve Touboulic,Sylvie Guérin,Gwénaëlle Randuineau,David Martin,Véronique Romé,Charles-Henri Malbert,Frédéric Derbré,David Val-Laillet,Ronan Thibault

Clinical Nutrition（2022）

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摘要

All these findings support that this experimental minipig model of severe malnutrition is valid to mimic pathophysiological changes occurring in human protein-energy marasmus malnutrition and muscle atrophy associated with malnutrition, as observed in patients with secondary sarcopenia.

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关键词

Undernutrition,Muscle atrophy,Energy metabolism,Sarcopenia,Protein synthesis

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