Herpesvirus Infections in the Human Brain: A Neural Cell Model of the Complement System Derived from Induced Pluripotent Stem Cells.

Ernesto T A Marques,Matthew Demers,Leonardo D'Aiuto,Priscila M S Castanha,Jason Yeung,Joel A Wood,Kodavali V Chowdari,Wenxiao Zheng,Robert H Yolken,Vishwajit L Nimgaonkar

Current topics in behavioral neurosciences（2023）

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摘要

hiPSC-derived co-culture models can be used to study viral infection in the brain, particularly complement receptor and function in relation to cellular "crosstalk." The models could be refined to further investigate pathogenic mechanisms.

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关键词

Brain,Brain development,Co-culture,Complement system,Microbial infections,Neurological diseases,Viral infection,iPSC

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