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老年ARDS患者血清FGF-21,GDF-15及PTX-3表达水平及其与病情评估和预后的相关性研究

Journal of Modern Laboratory Medicine(2022)

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Abstract
目的 探讨血清成纤维细胞生长因子21(fibroblast growth factor 21,FGF-21)、生长分化因子15(growth differentiation factor 15,GDF-15)及正五聚蛋白3(pentamerin 3,PTX-3)水平对老年急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)患者病情评估及预后预测的价值.方法 选取2019年1月~2021年12月儋州市人民医院收治的125例老年ARDS患者,根据氧合指数(oxygenation index,OI)将老年ARDS患者分为轻度组(n=32)、中度组(n=53)和重度组(n=40),根据入重症监护室(intensive care unit,ICU)30天内的生存情况将老年ARDS患者分为存活组(n=76)和死亡组(n=49).检测老年ARDS患者发病当天血清FGF-21,GDF-15及PTX-3水平.应用多因素Logistic回归分析影响老年ARDS患者死亡的危险因素,绘制ROC曲线分析血清FGF-21,GDF-15及PTX-3水平对老年ARDS患者预后预测的价值.相关性分析采用Pearson相关.结果 死亡组血清FGF-21(3268.37±456.27 pg/ml),GDF-15(3605.20±419.35 pg/ml)及PTX-3(27.15±8.72ng/ml)水平均明显高于存活组(950.24±130.28pg/ml,1468.15±247.30 pg/ml,13.40±4.16 ng/ml),差异有统计学意义(t=17.361,16.240,14.802,均P<0.001).重度组血清FGF-21(3709.24±524.17 pg/ml),GDF-15(4150.83±507.42 pg/ml)及PTX-3(31.28±10.26 ng/ml)水平均明显高于中度组(2587.60±347.25 pg/ml,2889.25±385.26 pg/ml,19.45±5.83 ng/ml)和轻度组(621.38±103.14 pg/ml,1007.36±194.12 pg/ml,11.27±2.90 ng/ml),差异有统计学意义(F=20.153,18.216,17.615,均P<0.001).多因素Logistic回归分析显示,OI低(OR=2.375,95%CI:1.502~5.113),APACHEⅡ评分(OR=2.803,95%CI:1.985~6.926),SOFA评分(OR=1.716,95%CI:1.208~3.412),FGF-21(OR=3.205,95%CI:2.647~9.683),GDF-15(OR=2.490,95%CI:1.712~5.770)及PTX-3(OR=3.104,95%CI:2.573~9.184)水平升高是影响ARDS患者死亡的危险因素(均P<0.05).ROC曲线显示,FGF-21,GDF-15及PTX-3三项联合预测老年ARDS患者死亡的AUC最大(0.957,95%CI:0.897~0.998).相关分析显示,ARDS死亡患者血清FGF-21水平与GDF-15,PTX-3均呈正相关(r=0.842,0.870,均P<0.001).结论 血清FGF-21,GDF-15及PTX-3水平升高与老年ARDS患者病情较重和死亡有关,三项联合检测能较好地预测老年ARDS患者的预后.
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