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Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury

Weihuang Qiu,Sheng An,Tingjie Wang,Jiaxin Li,Binmei Yu,Zhenhua Zeng,Zhongqing Chen,Bo Lin,Xianzhong Lin,Youguang Gao

International Immunopharmacology（2022）

Cited 20|Views19
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Abstract
•Ferroptosis levels increased in sepsis-induced acute kidney injury mouse model.•Ferostatin-1 inhibits Ferroptosis and alleviates sepsis-induced acute kidney injury.•Melatonin improves sepsis-induced acute kidney injury by inhibiting Ferroptosis.•Melatonin inhibits Ferroptosis via up regulating Nrf2/HO-1.
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Key words
Melatonin,Sepsis,Acute kidney injury,Ferroptosis,HO-1,Nrf2
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