Osteoclasts/Osteoblasts

Bone is a dynamic tissue which is constantly renewed by a precise balance between osteoblastic bone formation and osteoclastic bone resorption. This process is important for normal bone mass and strength, and for mineral homeostasis. Bone remodeling is stringently regulated by communication between bone cells such as osteoclasts, osteoblasts and osteocytes and by systemic factors. An imbalance can result in bone diseases including osteoporosis. Resorption by osteoclasts precedes bone formation by osteoblasts. The osteocytes, within the bone matrix, contribute to the control of bone remodeling. In this article, we present the current knowledge of the structure, characteristics and functions of bone cells.