Tannic Acid, as a Structural Moiety Coupled to a Protein Antigen, Exhibiting a Molecular-structure Adjuvant Activity for Antibody Specificity Enhancement.

Brenda Molina-Ramírez,Nidia Cabral-Hipólito,Irais Castillo-Maldonado,Dealmy Delgadillo-Guzmán,Rocío Meza-Velázquez,Agustina Ramírez-Moreno,Erika Flores-Loyola,Pablo Ruíz-Flores,Jorge Haro-Santa Cruz,Perla-Karina Espino-Silva,Joaquín Avalos-Soto,Miguel-Ángel Téllez-López, Rubén Daniel Arellano Pérez Vertti, Manuel-Gerardo Rosales-González,David Pedroza-Escobar

Protein and peptide letters（2022）

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摘要

Tannic acid exhibited macrophages' activation properties. Moreover, when TA was incorporated into the structure of a protein antigen, such as BSA, an antibody specificity enhancement was observed. This was a consequence of antigen processing by activated antigen-presenting cells. These results showed the use of tannic acid as a novel candidate for vaccine molecular-structure adjuvant.

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关键词

Adjuvant,cell-mediated immunity,humoral immunity,immunogenicity,tannic acid,vaccine adjuvant

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