Informal care in Huntington's disease: Assessment of objective-subjective burden and its associated risk and protective factors

•Informal care markers help monitor the disease severity course in Huntington's disease.•Objective-subjective burden courses mirror patterns of neuro-psychiatric impairments.•The multiplex status of caregivers in Huntington's disease was partially associated with increased burden.•Real-world ecological data such as burden scores identify uncovered care needs.