GluN2C selective inhibition is a target to develop new antiepileptic compounds.

Svetlana Gataullina, Gilles Galvani,Sabrina Touchet, Caroline Nous,Éric Lemaire,Jacques Laschet,Catherine Chiron,Olivier Dulac,Elena Dossi,Jean-Daniel Brion,Samir Messaoudi,Mouad Alami,Gilles Huberfeld

Epilepsia（2022）

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摘要

Subunit-selective inhibition is a valuable target for developing drugs for severe epilepsies resulting from an upregulation of NMDA-R subunit-mediated transmission.

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关键词

NMDA receptor,Tsc1 mice,child,electroencephalography,epilepsy,focal cortical dysplasia,multielectrode array,patch clamp,seizures,tuberous sclerosis complex

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