ENVIRONMENTAL CONTAMINANTS AND PLACENTAL TRANSPORTERS: EXAMPLE of PCB EXPOSURE and SLC AND ABCB1 EXPRESSION

Aim: Due to the environmental usage, these substances can be applied to the placental blood industry due to the shelves and the deteriorated membrane transportation. It is intended that their environmental effects can be influenced by these transport proteins. Materials and Methods: Within the scope of the study, in the placenta of the owner and endotheliochorial dog; Good by analysis of 28 good (PCB, PBDE, PAH and Organic chlorinated pesticides); The expression profile of the placental whole genome was investigated by RNAseq, evaluated in silico (mole clamping) and in vitro (SLC and ABCB1 mRNA analysis in the placental cell line HTR8/SVneo treated with PCB 101, PCB118). Results: PCB101 826.4μg/kg in one of the 60 samples tested; In 23 samples, PCB118 was found to be between 0.14 and 41.9μg/kg. In 55 samples in the sequence analysis in bioinformatics, PCB was found in 742 genes between positive and negative (p