Efficient Synthesis of the Key Intermediate of Scopolamine by [4+3] Cycloaddition Reaction
Letters in Organic Chemistry(2023)
Abstract
Scopolamine, as an anticholinergic agent, plays a regulatory role in the peripheral nervous system. In this paper, 6,7-dehydrotropinone, which is the key intermediate of scopolamine, is synthesized in moderate yield through [4+3] cyclization reaction and Barton deoxygenation reaction. This route has good application prospects with mild reaction conditions, moderate yield, and simple operating procedures.
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Key words
cycloaddition reaction,scopolamine,efficient synthesis
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