Cumulative Dialytic Glucose Exposure is a Risk Factor for Peritoneal Fibrosis and Angiogenesis in Pediatric Patients Undergoing Peritoneal Dialysis Using Neutral-pH Fluids

Yoko Shirai,Kenichiro Miura,Takeshi Ike,Kensuke Sasaki,Kiyonobu Ishizuka,Shigeru Horita,Sekiko Taneda,Daishi Hirano,Kazuho Honda,Yutaka Yamaguchi,Takao Masaki,Motoshi Hattori

Kidney International Reports（2022）

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摘要

Cumulative dialytic glucose exposure is an independent risk factor for peritoneal fibrosis and angiogenesis in pediatric patients undergoing PD using neutral-pH fluids, which might be associated with greater VEGF-α production by myofibroblasts implying a hypoxic response.

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关键词

fibrosis,pediatric nephrology,peritoneal dialysis,peritoneal membrane

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