The mechanisms underlying the pharmacological effects of GuiPi decoction on major depressive disorder based on network pharmacology and molecular docking.

Liyuan Chen,Tianyuan Ye,Xiaolong Wang,Lu Han,Tongxing Wang,Dongmei Qi,Xiaorui Cheng

Combinatorial chemistry & high throughput screening（2022）

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摘要

Different compounds in GPD may target the same protein, and the same component in GPD can target multiple targets. These results suggest that the effects of GPD on MDD are holistic and systematic, unlike the pattern of one drug-one target.

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关键词

GuiPi decoction,benzo[a]carbazole.,girinimbine,major depressive disorder,trifolin

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