Extracellular vesicles produced by bone marrow mesenchymal stem cells overexpressing programmed death-ligand 1 ameliorate dextran sodium sulfate-induced ulcerative colitis in rats by regulating Th17/Treg cell balance through PTEN/PI3K/AKT/mTOR axis.
Journal of gastroenterology and hepatology（2022）
Abstract
PD-L1-EVs mitigated colonal inflammation, apoptosis and oxidative stress through blocking the activation of PI3K/Akt/mTOR pathway and regulating the balance of Th17/Treg cells.
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Key words
PTEN/PI3K/AKT/mTOR axis,bone marrow-derived mesenchymal stem cells,extracellular vesicles,programmed death-ligand 1,ulcerative colitis
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