Design, Synthesis, Molecular Docking of Some New Polyhydrobenzothieno- thiazolopyrimidinedione Glycoside Derivatives with Double Anti-microbial-Anti- inflammatory Action

A novel series of thienopyrimidinone glycoside derivatives 7a-e or 8a-e were synthesized from the reaction of 2-mercapto-theino-pyrimidinone derivtives 3 and 4 or theino-thiazolopyrimidinone 5 and 6 with different aldo-sugars either hexoses or pentoses, The structure of the new resulted compounds were elucidated using IR, 1-HNMR, 13C-NMRspectra and elemental analysis. The compounds 2a, 2b,3,4,7a-e and 8a-e were screened against seven of pathogenic bacteria and one of fungus using Cprofloxacin and Bavistin as standard respectively. Also, measurement of Minimum Inhibitory Concentration (MIC) was made and showing that compounds 2a, 7a and 7d had the height results and near to the standard. Anti-inflammatory study was made for the fourteen compounds against Lipoxygenase "LOX",cyclooxygenase "COX 1" cyclooxygenase "COX 2" which revealed that compounds 2a, 7a and 7d had the best values among the series and good results when compared with the standard. Ipubrofen and indomethacin. Moreover molecular docking studies were done on the three compounds 2a, 7a and 7d. This study confirmed the dual action of our compounds as antimicrobial and anti-inflammatory agents