Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity

Razan Orfali,Young-Woo Nam,Hai Minh Nguyen,Mohammad Asikur Rahman, Grace Yang,Meng Cui,Heike Wulff,Miao Zhang

Cell Calcium（2022）

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摘要

•Disease-causing mutations elevated the apparent Ca2+ sensitivity of KCa2.3 channels.•Disease-causing mutations elevated the apparent Ca2+ sensitivity of KCa3.1 channels.•KCa2.3 and KCa3.1 channels are regulated differentially by the HA/HB helices.•AP14145 reduced the Ca2+ sensitivity of disease related mutant KCa2.3 channels.

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关键词

HA/HB helices,S45A/S45B helices,KCa2.3 and KCa3.1 channels,Negative gating modulator

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