Human acute leukemia uses branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function

Yoshikane Kikushige,Toshihiro Miyamoto,Yu Kochi,Yuichiro Semba,Maki Ohishi,Hidetoshi Irifune,Kiwamu Hatakeyama,Yuya Kunisaki,Takeshi Sugio,Teppei Sakoda,Kohta Miyawaki,Koji Kato,Tomoyoshi Soga,Koichi Akashi

Blood advances（2023）

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摘要

•Human acute leukemia cells form a unique metabolic circuit for sustaining BCAA catabolism activity without α-KG exhaustion.•BCAA metabolism represents a novel regulator of PRC2 to maintain the stemness of acute leukemia.

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关键词

human acute leukemia,acute leukemia,amino acid,stemness,branched-chain

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