Pentoxifylline/Valsartan co-delivery in liposomal gel alters the inflammatory HMGB-1/ TLR pathway and promotes faster healing in burn wounds: A promising repurposed approach

•The effect of PTX and VAL simultaneously in a nanometric liposomal delivery system for the treatment of burn ulcer.•Innovation in multiloading liposomal stable drug delivery system with two drugs of different classes with appropriate entrapment efficiency.•The pharmacological mechanism of a combined therapy in ulcer management.•A new simple, economic and reliable validated spectrophotometric method for the co– analysis of PTX and VAL in the final delivery product was also developed.