Next generation sequencing reveals miR-431–3p/miR-1303 as immune-regulating microRNAs for active tuberculosis

Yung-Che Chen,Chang-Chun Hsiao,Chao-Chien Wu,Tung-Ying Chao,Sum-Yee Leung,Yu-Ping Chang,Chia-Cheng Tseng,Chiu-Ping Lee,Po-Yuan Hsu,Ting-Ya Wang,Po-Wen Wang,Ting-Wen Chen,Meng-Chih Lin

Journal of Infection（2022）

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摘要

•Whole genome sequencing identified 55 TB-related differentially expressed microRNAs.•Proteoglycan, longevity, apoptosis, central carbon metabolism, and autophagy were enriched target pathways.•miR-431–3p down-regulation and miR-1303 up-regulation were verified in vivo & vitro.•miR-431–3p over-expression and miR-1303 knock-down improved macrophage functions synergistically.•Both microRNAs regulate autophagy, apoptosis, and phagocytosis via targeting MDR1/MMP16/RIPOR2 and ATG5.

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关键词

Pulmonary tuberculosis,MicroRNA-431–3pRNA,MicroRNA-1303RNA,Autophagy,Apoptosis,Phagocytosis

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