Genetic disruption of the Gipr in Apoe -/- mice promotes atherosclerosis.
Molecular metabolism（2022）
Abstract
Loss of the Gipr in mice results in increased aortic atherosclerosis and enhanced inflammation in aorta and liver, despite reduced weight gain and preserved glucose homeostasis. These findings extend concepts of GIPR in the suppression of inflammation-related pathophysiology beyond its classical incretin role in the control of metabolism.
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Key words
Glucose-dependant insulinotropic polypeptide receptor,atherosclerosis,blood vessel,cholesterol,incretin,inflammation
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