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Dynamic alteration and prognostic significance of tumor‐associated CD68 + and CD68 + PD‐L1 − macrophages in muscle‐invasive bladder cancer treated with neoadjuvant chemotherapy

Jie Wu,Rui‐Yang Xie,Li‐Hui Wei,Chuan‐Zhen Cao,Bing‐Qing Shang,You‐Yan Guan,Hong‐Zhe Shi,Wang Qu, Yun Li,Jing Liang,Shan Zheng,Ai‐Ping Zhou,Xiao‐Feng Zhou,Jian‐Zhong Shou,Xin‐Gang Bi

Cancer Medicine（2022）

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Abstract
CD68 and CD68 PD-L1 TAMs infiltration levels decreased significantly after NAC and pre-treatment TAM infiltration levels were independent prognostic factors for MIBC patients. While there was no sufficient evidence demonstrating that pre-treatment TILs or TAMs could predict response to NAC in MIBC patients.
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multiplex immunofluorescence staining,muscle-invasive bladder cancer,neoadjuvant chemotherapy,prognosis,tumor-associated macrophages
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