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Irisin improves BBB dysfunction in SAP rats by inhibiting MMP-9 via the ERK/NF-κB signaling pathway

Peipei Guo,Lan Liu, Xin Yang,Mengting Li,Qiu Zhao,Huisheng Wu

Cellular Signalling（2022）

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Abstract
•Irisin alleviates the BBB dysfunction by enhancing MMP-9 mediated tight junctions through ERK/NF-kB pathway in SAP•Irisin has a neuroprotective effect on pancreatic encephalopathy
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Key words
Irisin,Severe acute pancreatitis,Extracellular signal-regulated kinase,Blood–brain barrier,MMP-9
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