Comparative effect of delapril-manidipine treatment versus valsartan-amlodipine treatment in HOMA-IR, HOMA-B, HOMA-S and QUICKI indexes in prediabetic hypertensive patients

Background and Aims: Prediabetes is often present in patients with arterial hypertension. The effect of various antihypertensive drugs on the glucose homeostasis has been discussed extensively. Dual combination treatment is advised with current guidelines. We present comparative data of the effect of valsartan/amlodipine versus delapril/manidipine combination treatments, in HOMA-IR, HOMA-B, HOMA-S AND QUICKI indices before and after the 3-month treatment, in hypertensive prediabetic patients.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Conclusions: From the studied population, no significant differences were observed between treatment groups’ comparison, for all parameters after the 3-month treatment. For the VAL/AMLO treatment group there have been noted statistically insignificant increases in HOMA-IR (+12.65%) and HOMA-B (+17%). Finally, no change has been observed in QUICKI values, while in the DEL/MANI for the HOMA-IR and QUICKI, there were no significant variance, while HOMA-B values showed a statistically significant increase (7%, p=0.006). Background and Aims: Prediabetes is often present in patients with arterial hypertension. The effect of various antihypertensive drugs on the glucose homeostasis has been discussed extensively. Dual combination treatment is advised with current guidelines. We present comparative data of the effect of valsartan/amlodipine versus delapril/manidipine combination treatments, in HOMA-IR, HOMA-B, HOMA-S AND QUICKI indices before and after the 3-month treatment, in hypertensive prediabetic patients. Conclusions: From the studied population, no significant differences were observed between treatment groups’ comparison, for all parameters after the 3-month treatment. For the VAL/AMLO treatment group there have been noted statistically insignificant increases in HOMA-IR (+12.65%) and HOMA-B (+17%). Finally, no change has been observed in QUICKI values, while in the DEL/MANI for the HOMA-IR and QUICKI, there were no significant variance, while HOMA-B values showed a statistically significant increase (7%, p=0.006).