Comparative effect of valsartan-amlodipine treatment versus telmisartan-amlodipine treatment in HOMA-IR, HOMA-B, HOMA-S and QUICKI indexes in prediabetic hypertensive patients

Background and Aims: According to the latest ESC guidelines for hypertension treatment, it is recommended to use combination therapy of 2 antihypertensive agents as a starting point for most patients. The effect of these drugs on the glucose homeostasis has been discussed extensively. Many hypertensive patients are at risk of developing diabetes as are already in a prediabetic state. We present comparative data of the effect of valsartan/amlodipine versus telmisartan/amlodipine combination treatments, in HOMA-IR, HOMA-B, HOMA-S AND QUICKI indices before and after the 3-month treatment, in hypertensive prediabetic patients.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Conclusions: Patients in the TEL/AMLO group had significantly lower insulin resistance as shown by the HOMA-IR index compared with the patients that received valsartan and amlodipine (p <0.001). Furthermore, QUICKI index was significantly increased in the TEL/AMLO group compared with the VAL/AMLO group (p<0.01). Background and Aims: According to the latest ESC guidelines for hypertension treatment, it is recommended to use combination therapy of 2 antihypertensive agents as a starting point for most patients. The effect of these drugs on the glucose homeostasis has been discussed extensively. Many hypertensive patients are at risk of developing diabetes as are already in a prediabetic state. We present comparative data of the effect of valsartan/amlodipine versus telmisartan/amlodipine combination treatments, in HOMA-IR, HOMA-B, HOMA-S AND QUICKI indices before and after the 3-month treatment, in hypertensive prediabetic patients. Conclusions: Patients in the TEL/AMLO group had significantly lower insulin resistance as shown by the HOMA-IR index compared with the patients that received valsartan and amlodipine (p <0.001). Furthermore, QUICKI index was significantly increased in the TEL/AMLO group compared with the VAL/AMLO group (p<0.01).