Genetic and epigenetic regulation of nc886 RNA levels and their association to cardiometabolic phenotypes

Background and Aims : A non-coding nc886 RNA is transcribed from a polymorphically imprinted metastable epiallele. Methylation status of this locus is affected by the periconceptional conditions and both the methylation status and the level of nc886 RNAs are shown to be associated with health traits in later life. We have previously shown that, in addition to the methylation status of the nc886 locus, genetics have an independent effect on nc886 RNA levels. As genotypic and methylation data are more commonly available in existing population cohorts than RNA levels, we set out to investigate whether we can leverage this information to further study the cardiometabolic associations of nc886 RNAs.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Conclusions: Our hope for the future is to use this variable to study the effect of nc886 RNA levels across different cohorts and further explore the association between nc886 levels and the relevant cardiometabolic phenotypes. Background and Aims : A non-coding nc886 RNA is transcribed from a polymorphically imprinted metastable epiallele. Methylation status of this locus is affected by the periconceptional conditions and both the methylation status and the level of nc886 RNAs are shown to be associated with health traits in later life. We have previously shown that, in addition to the methylation status of the nc886 locus, genetics have an independent effect on nc886 RNA levels. As genotypic and methylation data are more commonly available in existing population cohorts than RNA levels, we set out to investigate whether we can leverage this information to further study the cardiometabolic associations of nc886 RNAs. Conclusions: Our hope for the future is to use this variable to study the effect of nc886 RNA levels across different cohorts and further explore the association between nc886 levels and the relevant cardiometabolic phenotypes.