Synthesis of dehydromuscone by an alkene metathesis macrocyclization reaction at 0.2 M concentration

The synthesis of the industrial fragrance compound dehydromuscone is accomplished here in five linear steps in 19% overall yield, featuring a highly efficient, non–diluted ring–closing metathesis macrocyclization reaction as the key step, which proceeds at 0.2 M concentration with 0.1 mol% Nitro–Grela catalyst. The synthesis employs commercially available, linear starting materials and shortens, in at least two steps, the current industrial synthetic route.