过量甲氨蝶呤中毒引起的皮肤损害1例
Journal of Diagnosis and Therapy on Dermato-venereology（2022）
Abstract
报告1例过量甲氨蝶呤中毒引起的皮肤损害.患者女,74岁,全身红斑脱屑伴疼痛8 d.入院前连续10 d口服MTX 5 mg/d,累积剂量50 mg,服药第3天全身出现红斑脱屑.皮肤科检查:口腔黏膜糜烂,躯干四肢弥漫分布红斑,表面脱屑,部分可见糜烂渗出,以四肢受累为主.完善相关实验检查提示白细胞及血小板减少,转氨酶升高.诊断:甲氨蝶呤中毒.治疗:口服亚叶酸钙解毒,加强水化,碱化尿液,促进血小板及白细胞升高,护肝,外用药物及对症支持治疗,2周后好转出院.目前病情平稳,正在随访中.
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