Curcumin attenuates chronic intermittent hypoxia-induced brain injuries by inhibiting AQP4 and p38 MAPK pathway.
Respiratory Physiology & Neurobiology（2018）
Abstract
•Chronic intermittent hypoxia induces brain edema and astrogliosis in mice.•Chronic intermittent hypoxia increases AQP4 expression and activates p38 MAPK pathway.•Curcumin inhibits AQP4 and p38MAPK pathway in chronic intermittent hypoxia-exposed mice.•Improved effect of curcumin on chronic intermittent hypoxia-induced brain damage.
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Key words
Curcumin chronic intermittent hypoxia,Brain edema,Astrogliosis,AQP4,p38 MAPK
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