Genetic determinants of activated factor vii-antithrombin complex (fviia-at) plasma levels and mortality in patients with angiographically demonstrated coronary artery disease

Francesca Pizzolo,Mariangela Veneri, Filippo Sartori,Nicola Osti, Martino Donini,Sara Moruzzi,Filippo Mazzi,Annalisa Castagna,Silvia Udali,Patrizia Pattini,Barbara Lunghi,Marcello Baroni,Francesco Bernardi,Oliviero Olivieri,Simonetta Friso,Nicola Martinelli

Journal of hypertension（2022）

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摘要

Polymorphisms in TF, EPCR, and F7 genes may contribute to the modulation of FVIIa-AT plasma levels. Results on the different genotypes suggest that the mechanisms originating the increase of FVIIa-AT plasma concentration may have a key role in CAD prognosis, addressing the interest on TF pathway.

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