Loss of α4A- and β1-tubulins leads to severe platelet spherocytosis and strongly impairs hemostasis in mice

Quentin Kimmerlin,Sylvie Moog,Alexandra Yakusheva, Catherine Ziessel,Anita Eckly,Monique Freund,Gábor Závodszky,Yannick Knapp,Pierre Mangin,François Lanza

Blood（2022）

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摘要

•Platelets lacking α4A- and β1-tubulins are devoid of marginal band and fully spherical and inefficiently interact with matrices under flow.•Mice deficient for α4A- and β1-tubulins exhibit severe defects in hemostatic and thrombotic responses in vivo.

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severe platelet spherocytosis,hemostasis

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