The molecular features of chronic lung allograft dysfunction in lung transplant airway mucosa

The Journal of Heart and Lung Transplantation（2022）

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摘要

Mucosal and transbronchial biopsies from CLAD patients reveal a diffuse molecular injury and dedifferentiation state that impacts prognosis and correlates with the physiologic disturbances. CLAD state in lung transplants shares features with failing kidney transplants, indicating elements shared by the injury responses of distressed organs.

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关键词

gene expression,injury,chronic lung allograft dysfunction,airway

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