Interaction of membrane vesicles with the Pseudomonas functional amyloid protein FapC facilitates amyloid formation

Zahra Najarzadeh,Hossein Mohammad-Beigi,Jannik Nedergaard Pedersen,Gunna Christiansen,Jan Skov Pedersen,Janni Nielsen,Daniel E. Otzen

SSRN Electronic Journal（2022）

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摘要

•Anionic DMPG vesicles promote FapC fibrillation below and above the lipid tm.•Zwitterionic (DMPC, DOPC) have no effect on FapC fibrillation while DOPG did not show a clear effect.•Heating of FapC induces higher β-sheet content and rapid fibrillation.•FapC imperfect repeat 2 is important for reversibility of thermal changes.•EGCG inhibits FapC-DMPG contacts and redirects FapC to off-pathway oligomers.

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关键词

bacterial amyloid,FapC protein,membrane vesicle,EGCG,ThT kinetics

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