Development and Evaluation of a Novel Software Program, SAKURA-TDM, for Area Under the Concentration-Time Curve-Guided Vancomycin Dosing: A Short Communication.

Yasuhiro Horita,Minami Asaoka,Moeko Iida, Hideki Kato,Chiharu Wachino, Kana Mitamura,Kazuki Ohashi,Yoshihisa Mimura,Yuji Hotta,Tomoya Kataoka,Atsushi Nakamura,Kazunori Kimura

Therapeutic drug monitoring（2023）

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Abstract

We demonstrated the equivalence of the estimated PK parameters between SAKURA-TDM and other TDM software programs available in Japan. Considering the threshold of both trough values and the steady-state AUC and monitoring of the AUC in a non-steady state, it would be possible to reduce the risk of vancomycin-associated renal injury.

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Key words

software for TDM, vancomycin, AUC

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